» » Farnesyltransferase Inhibitors in Cancer Therapy

Information of news
30-04-2015, 01:11

Farnesyltransferase Inhibitors in Cancer Therapy

Category: E-Books

Farnesyltransferase Inhibitors in Cancer Therapy
Saïd M. Sebti, Andrew D. Hamilton - Farnesyltransferase Inhibitors in Cancer Therapy
Published: 2000-11-22 | ISBN: 0896036294, 1468496069 | PDF | 280 pages | 3 MB

With the explosion of research on genes capable of causing cancer, it has become clear that mutations in the GTPase, Ras, a major regulator of cell division, are found in about 30% of all human cancers, and that farnesylation, a lipid posttranslational modification of Ras, is required for its cancer-causing activity. In , cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farnesyltransferase inhibitors (FTIs) and geranylgeranyltransferase inhibitors (GGTIs) that can be used as anticancer drugs and in cardiovascular and parasitic therapy. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other cytotoxic agents, such as gemcitabine, cisplatin, and taxanes. The book also discusses the results from several phase I and II human clinical trials using a variety of FTIs, and demonstrates the design of hypothesis-driven clinical trials with proof-of-concept using biochemical endpoints.
Illuminating and richly detailed, constitutes today's standard reference for the pathbreaking use of FTIs and GGTIs in anticancer therapy and offers basic and clinical investigators a comprehensive treatment of the scientific and medical aspects of farnesyltransferase inhibitors.



Site BBcode/HTML Code:
Dear visitor, you went to the site as unregistered user.
We recommend you Sign up or Login to website under your name.
Would you like to leave your comment? Please Login to your account to leave comments. Don't have an account? You can create a free account now.

Tag Cloud

archive of news

free html hit counter